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Document Type |
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Article In Journal |
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Document Title |
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A Convenient Synthesis of Thiazolo [ 3,2-a } - & Triazolo [ 4,3-a ]- Pyrimidines & Pyrimido [ 2,1-c ] Triazine Derivatives تحضير ثيازولو [2،3 -أ ] - وتريازولو [3،4 - أ] بيريميدينات ومشتقات بيريميدو [ 1،2 - جـ ] تريازين |
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Subject |
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Chemistry |
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Document Language |
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English |
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Abstract |
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Alkylation of 4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-
5-carbonitrile (1) gave the S-alkyl derivatives (2b,c).
Compound (2c) could be cyclised into 3-methyl-5-oxo-5H-7- phenylthiazolo[
3,2-a] pyrimidine-6-carboxamide (3). Further substitution of
compounds (2a,b) yielded the N3-Substituted pyrimidine derivatives
(7a-e). Desulphunisation of each of compounds (2a,b) with benzhydrazide
resulted in the formation of 2-(2-benzoylhydrazino)- pyrimidine
derivative (9) , which could be converted into the
triazolo[4,3-a] pyrimidine (11). Each of compounds (2a,b) reacted
with semicarbazide to produce directly the dioxotriazolopyrimidine
derivative (14). Treatment of the 2-hydrazinopyrimidine derivative
(10) with chloroacetyl chloride afforded the pyrimido[2,1-c]triazine
derivative (16). Its isomeric compound (17) could be also prepared.
The structures of the newly synthesized compounds were proved by
chemical routes and spectral studies. |
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ISSN |
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1012-1319 |
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Journal Name |
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Science Journal |
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Volume |
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12 |
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Issue Number |
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1 |
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Publishing Year |
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1420 AH
2000 AD |
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Number Of Pages |
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15 |
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Article Type |
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Article |
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Added Date |
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Sunday, October 11, 2009 |
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Researchers
| محمد علي هيازع | M. A. Haiza | Researcher | | |
| سعيد عبدالله عسيري | S. A Assiery | Researcher | | |
| محمد صبري مصطفى | M. S. Mostafa | Researcher | | |
| أحمد محمد الريدي | A. M. El-Reedy | Researcher | | |
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