Document Details

Document Type : Article In Journal 
Document Title :
The Uncoupling of Oxidative Phosphorylationof Mouse-Liver Mitochondria in vivo by Usnic Acid
منع تزامن الفسفرة التأكسدية في ميتوكوندريا كبد الفأرة الحي بواسطة حمض الأوزينك
 
Subject : Biological Sciences 
Document Language : English 
Abstract : (+) Usnic acid isolated from the local lichen species Usnea articulata had a median lethal dose of 180 mg/kg to mice (s.c. injection).The symptoms of the toxicity exhibited by (+) usnic acid was similar to those of classical uncouplers of oxidative phosphorylation.Mice injected with 200 mg/kg of (+) usnic acid produced significant uncoupling of isolated hepatic mitochondria. The signs of uncoupling included: release of respiratory control, inhibition of respiration (80% in the presence of ADP and 60% in its absence), hindering of ATP biosynthesis,and stimulation of Mg+2-ATPase activity (two-fold increase).In this respect, (+) usnic acid, a lipophilic weak acid with two ionizable hydrogens, acts in a similar fashion to many protonophoric uncouplers which dissipate the proton motive force (delta mu H+) across the inner mitochondrial membrane, therefore disrupting the tight coupling mechanism between electron transport and ATP synthesis. 
ISSN : 1012-1319 
Journal Name : Science Journal 
Volume : 17 
Issue Number : 1 
Publishing Year : 1425 AH
2005 AD 
Number Of Pages : 10 
Article Type : Article 
Added Date : Sunday, October 11, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أحمد نبيل أبو خطوة AHMED N. ABO-KHATWAResearcher  
علي أحمد الرباعي ALI A. AL-ROBAIResearcher  
دينا عبدالعزيز الجوهريDINA A. AL-JAWHARIResearcher  

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