|
Document Type |
: |
Article In Journal |
|
Document Title |
: |
Synovial Fluid and Serum Levels of sE-Selectin, IL-1? and TNF-? in Rheumatoid Arthritis Patients قياس مستويات الإسلكتين والإنترلوكين -1- بيتا وعامل النخر الورمي ألفا في السائل الزليلي ومصل مرضى الرثيان المفصلي |
|
Subject |
: |
Original Articles |
|
Document Language |
: |
English |
|
Abstract |
: |
This work aims at determining the difference of proinflammatory
cytokines, adhesion molecules in synovial fluid, serum
of rheumatoid arthritis, osteoarthritis patients Synovial fluid and
serum were obtained from rheumatoid arthritis (n = 21), osteoarthritis
(n = 11) patients, serum of healthy individuals (n = 12). Interleukin-
1?, tumor necrosis factor-alpha, sE-selectin levels were measured by
Enzyme-Linked Immunosorbent Assay Test. Compared to controls, SsE-
selectin was significantly elevated in rheumatoid arthritis while SIL-
1?, S-TNF-? were elevated in rheumatoid arthritis and
osteoarthritis patients. S-sE-selectin, SF-IL-1? and SF-TNF-? were
significantly elevated in rheumatoid arthritis versus osteoarthritis. In
rheumatoid arthritis, SF-sE-selectin was significantly lower while SFTNF-
? was higher than serum in rheumatoid arthritis and
osteoarthritis. In rheumatoid arthritis, positive correlation between SFE-
selectin with serum – C-reactive Protein and S-sE-selectin; between
S-sE-selectin with disease duration and S-TNF-?; between S-IL1-?
with SF-IL1-? and disease activity while negative correlationbetween
S-TNF-? with grip strength were found. A degree of vascular
endothelial activation reflected by increased sE-selectin, is associated
with disease activity, duration in rheumatoid arthritis. The positive
association between IL-1?, disease activity and negative association
between TNF-?, grip strength indicated that serial estimation of these
cytokines may be used to monitor disease progression. Elevated TNF-
? in synovial fluid than in serum of rheumatoid arthritis, osteoarthritis
patients indicates its local formation in the synovium. |
|
ISSN |
: |
1319-1004 |
|
Journal Name |
: |
Medical Science Journal |
|
Volume |
: |
14 |
|
Issue Number |
: |
1 |
|
Publishing Year |
: |
1428 AH
2007 AD |
|
Number Of Pages |
: |
15 |
|
Article Type |
: |
Article |
|
Added Date |
: |
Sunday, October 11, 2009 |
|
Researchers
| إيناس أحمد حامد | Enas A. Hamed | Researcher | | |
| إيمان أحمد حامد | Eman A. Hamed | Researcher | | |
| شريفة أحمد حامد | Sherifa A. Hameda | Researcher | | |
| هبةالله جمال راشد | Hebat-Allah J. Rashed | Researcher | | |
|